Hedgehog produced by the Drosophila wing imaginal disc induces distinct responses in three target tissues.
Development
; 147(22)2020 11 17.
Article
en En
| MEDLINE
| ID: mdl-33028613
ABSTRACT
Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of the Drosophila wing imaginal disc that produces Hh and is near the tracheal air sac primordium (ASP) and myoblasts. Hh distributes in concentration gradients in the anterior compartment of the wing disc, ASP and myoblasts, and activates genes in each tissue. Some targets of Hh signal transduction are common to the disc, ASP and myoblasts, whereas others are tissue-specific. Signaling in the three tissues is cytoneme-mediated and cytoneme-dependent. Some ASP cells project cytonemes that receive both Hh and Branchless (Bnl), and some targets regulated by Hh signaling in the ASP are also dependent on Bnl signal transduction. We conclude that the single source of Hh in the wing disc regulates cell type-specific responses in three discreet target tissues.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Alas de Animales
/
Transducción de Señal
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Proteínas de Drosophila
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Proteínas Hedgehog
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Discos Imaginales
Límite:
Animals
Idioma:
En
Año:
2020
Tipo del documento:
Article