Does pediatric heart transplant survival differ with various cardiac preservation solutions?
Clin Transplant
; 34(12): e14122, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-33058258
ABSTRACT
BACKGROUND:
Few studies directly compare outcomes between the most commonly used preservation solutions in pediatric heart transplantation in a large cohort of recipients. The purpose of this study is to investigate the effect of cardiac preservation solution on survival in pediatric heart transplant recipients.METHODS:
The United Network for Organ Sharing (UNOS) database was retrospectively reviewed from 01/2004-03/2018 for pediatric donor hearts. Saline, University of Wisconsin (UW), "cardioplegia," Celsior, and Custodiol preservation solutions were evaluated. The primary endpoints were recipient survival at 30 days, 1 year, and long term.RESULTS:
After exclusion criteria, 3012 recipients had preservation solution data available. The most common preservation solution used was UW in 1203 patients (40%), followed by Celsior in 542 (18%), cardioplegia in 461 (15%), saline in 408 (14%), and Custodiol in 398 (13%). Survival of recipients whose donor hearts were procured with UW was as follows 97%-30 day, 92%-1 year; Celsior 97%-30 day, 92%-1 year; cardioplegia 97%-30 day, 91%-1 year; saline 97%-30 day, 91%-1 year; and Custodiol 96%-30 day and 92%-1 year. Analysis of Cox models for 30-day and long-term survival revealed no statistical differences when comparing UW to Celsior (p = .333), cardioplegia (p = .914), saline (p = .980), or Custodiol (p = .642) in adjusted models.CONCLUSIONS:
There were no significant differences in 30-day or 1-year survival detected between commonly used preservation solutions in the pediatric heart transplant population.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Corazón
/
Soluciones Preservantes de Órganos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Child
/
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article