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Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5-[(4-chloro/2,4-dichloro)benzylidene]thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors.
El-Adl, Khaled; El-Helby, Abdel-Ghany A; Sakr, Helmy; Ayyad, Rezk R; Mahdy, Hazem A; Nasser, Mohamed; Abulkhair, Hamada S; El-Hddad, Sanadelaslam S A.
  • El-Adl K; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
  • El-Helby AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.
  • Sakr H; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
  • Ayyad RR; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
  • Mahdy HA; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
  • Nasser M; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
  • Abulkhair HS; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
  • El-Hddad SSA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Arch Pharm (Weinheim) ; 354(2): e2000279, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33073374
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Tiazolidinedionas / Inhibidores de Proteínas Quinasas / Simulación del Acoplamiento Molecular / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Tiazolidinedionas / Inhibidores de Proteínas Quinasas / Simulación del Acoplamiento Molecular / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article