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Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability.
Pradhan, Tejaswini; Annamalai, Karthikeyan; Sarkar, Riddhiman; Huhn, Stefanie; Hegenbart, Ute; Schönland, Stefan; Fändrich, Marcus; Reif, Bernd.
  • Pradhan T; Helmholtz-Zentrum München (HMGU), Deutsches Forschungszentrum für Gesundheit und UmweltInstitute of Structural Biology (STB), Neuherberg, Germany; Munich Center for Integrated Protein Science (CIPS-M) at the Dept. of Chemistry, Technische Universität München (TUM), Garching, Germany.
  • Annamalai K; Institute of Protein Biochemistry, Ulm University, Ulm, Germany.
  • Sarkar R; Helmholtz-Zentrum München (HMGU), Deutsches Forschungszentrum für Gesundheit und UmweltInstitute of Structural Biology (STB), Neuherberg, Germany; Munich Center for Integrated Protein Science (CIPS-M) at the Dept. of Chemistry, Technische Universität München (TUM), Garching, Germany.
  • Huhn S; Medical Department V, Multiple Myeloma Center, Heidelberg University Hospital, Heidelberg, Germany.
  • Hegenbart U; Medical Department V, Amyloidosis Center, Heidelberg University Hospital, Heidelberg, Germany.
  • Schönland S; Medical Department V, Amyloidosis Center, Heidelberg University Hospital, Heidelberg, Germany.
  • Fändrich M; Institute of Protein Biochemistry, Ulm University, Ulm, Germany.
  • Reif B; Helmholtz-Zentrum München (HMGU), Deutsches Forschungszentrum für Gesundheit und UmweltInstitute of Structural Biology (STB), Neuherberg, Germany; Munich Center for Integrated Protein Science (CIPS-M) at the Dept. of Chemistry, Technische Universität München (TUM), Garching, Germany. Electronic addr
J Biol Chem ; 295(52): 18474-18484, 2020 12 25.
Article en En | MEDLINE | ID: mdl-33093170
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cadenas Ligeras de Inmunoglobulina / Amiloidosis de Cadenas Ligeras de las Inmunoglobulinas / Amiloide / Mutación Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cadenas Ligeras de Inmunoglobulina / Amiloidosis de Cadenas Ligeras de las Inmunoglobulinas / Amiloide / Mutación Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article