Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer.

Zhou, Yuan; Bian, Shuhui; Zhou, Xin; Cui, Yueli; Wang, Wendong; Wen, Lu; Guo, Limei; Fu, Wei; Tang, Fuchou

Zhou, Yuan; Bian, Shuhui; Zhou, Xin; Cui, Yueli; Wang, Wendong; Wen, Lu; Guo, Limei; Fu, Wei; Tang, Fuchou.

Zhou Y; Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing 100871, China; Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 10
Bian S; Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing 100871, China; Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 10
Zhou X; Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing 100871, China.
Cui Y; Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing 100871, China; Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 10
Wang W; Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing 100871, China.
Wen L; Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing 100871, China; Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 10
Guo L; Department of Pathology, Peking University Third Hospital, School of Basic Medical Science, Peking University Health Science Center, Beijing 100871, China.
Fu W; Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing 100871, China. Electronic address: fuwei@bjmu.edu.cn.
Tang F; Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing 100871, China; Biomedical Pioneering Innovation Center, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 10

Cancer Cell ; 38(6): 818-828.e5, 2020 12 14.

Article en En | MEDLINE | ID: mdl-33096021

Asunto(s)

Biomarcadores de Tumor/genética; Cromosomas Humanos Par 7/genética; Neoplasias Colorrectales/genética; Variaciones en el Número de Copia de ADN; Perfilación de la Expresión Génica/métodos; Análisis de la Célula Individual/métodos; Biglicano/genética; Proteínas de Unión al Calcio/genética; Estudios de Casos y Controles; Femenino; Regulación Neoplásica de la Expresión Génica; Humanos; Masculino; Proteínas de Microfilamentos/genética; Proteínas Musculares/genética; Cadenas Ligeras de Miosina/genética; Pronóstico; Análisis de Secuencia de ARN; Células del Estroma/química; Tropomiosina/genética; Microambiente Tumoral

Palabras clave

colorectal cancer; somatic copy number alterations; stromal cell; tumor microenvironment

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 7 / Neoplasias Colorrectales / Biomarcadores de Tumor / Perfilación de la Expresión Génica / Variaciones en el Número de Copia de ADN / Análisis de la Célula Individual Tipo de estudio: Observational_studies / Prognostic_studies Límite: Female / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article

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