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A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
Stefano, James E; Lord, Dana M; Zhou, Yanfeng; Jaworski, Julie; Hopke, Joern; Travaline, Tara; Zhang, Ningning; Wong, Karen; Lennon, Amanda; He, Timothy; Bric-Furlong, Eva; Cherrie, Cornishia; Magnay, Tristan; Remy, Elisabeth; Brondyk, William; Qiu, Huawei; Radosevic, Katarina.
  • Stefano JE; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Lord DM; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Zhou Y; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA. Electronic address: Yanfeng.Zhou@sanofi.com.
  • Jaworski J; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Hopke J; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Travaline T; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Zhang N; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Wong K; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Lennon A; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • He T; Translational Sciences, Sanofi R&D, Cambridge, Massachusetts, USA.
  • Bric-Furlong E; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Cherrie C; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Magnay T; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Remy E; Sanofi R&D, Vitry, France.
  • Brondyk W; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Qiu H; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
  • Radosevic K; Biologics Research, Sanofi R&D Framingham, Massachusetts, USA.
J Biol Chem ; 295(52): 18379-18389, 2020 12 25.
Article en En | MEDLINE | ID: mdl-33122192
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos Fab de Inmunoglobulinas / 5'-Nucleotidasa / Neoplasias Pulmonares / Anticuerpos Monoclonales / Epítopos Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos Fab de Inmunoglobulinas / 5'-Nucleotidasa / Neoplasias Pulmonares / Anticuerpos Monoclonales / Epítopos Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article