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CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects.
Skaria, Tom; Wälchli, Thomas; Vogel, Johannes.
  • Skaria T; Institute of Veterinary Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
  • Wälchli T; Department of Fundamental Neurobiology, Krembil Research Institute, University Health Network, University of Toronto, Toronto, Canada; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Canada; Group of Brain Vasculature and Neurovascular Unit, Division of Neurosurgery, Department of Clinical Neurosciences, University Hospital Geneva, Geneva, Switzerland; Group of CNS Angiogenesis and Neurovascular Link, Institute
  • Vogel J; Institute of Veterinary Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland. Electronic address: jvogel@vetphys.uzh.ch.
Trends Mol Med ; 27(1): 7-10, 2021 01.
Article en En | MEDLINE | ID: mdl-33129692
Recently, the US FDA has authorized a drug repurposing trial with calcitonin gene-related peptide (CGRP) receptor antagonists to reduce lung inflammation in coronavirus 2019 (COVID-19). However, the well-established cardiopulmonary protective effects of CGRP raise concerns about the safety of antagonizing CGRP in COVID-19. Awareness regarding potential cardiopulmonary adverse effects may enable their early detection and prevent illness from worsening.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de Péptido Relacionado con el Gen de Calcitonina / Antagonistas del Receptor Peptídico Relacionado con el Gen de la Calcitonina / SARS-CoV-2 / COVID-19 / Tratamiento Farmacológico de COVID-19 / Cardiopatías Tipo de estudio: Screening_studies Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de Péptido Relacionado con el Gen de Calcitonina / Antagonistas del Receptor Peptídico Relacionado con el Gen de la Calcitonina / SARS-CoV-2 / COVID-19 / Tratamiento Farmacológico de COVID-19 / Cardiopatías Tipo de estudio: Screening_studies Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article