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Diagnostic Accuracy of Nipple Aspirate Fluid Cytology in Asymptomatic Patients: A Meta-analysis and Systematic Review of the Literature.
Jiwa, Natasha; Gandhewar, Rishikesh; Chauhan, Hemali; Ashrafian, Hutan; Kumar, Swathica; Wright, Corrina; Takats, Zoltan; Leff, Daniel Richard.
  • Jiwa N; Department of Surgery and Cancer, Imperial College London, London, UK. natasha.jiwa04@imperial.ac.uk.
  • Gandhewar R; Department of Surgery and Cancer, Imperial College London, London, UK.
  • Chauhan H; Department of Surgery and Cancer, Imperial College London, London, UK.
  • Ashrafian H; Department of Surgery and Cancer, Imperial College London, London, UK.
  • Kumar S; Royal College of Surgeons Ireland, Dublin, Ireland.
  • Wright C; Imperial College Healthcare Trust, London, UK.
  • Takats Z; Department of Surgery and Cancer, Imperial College London, London, UK.
  • Leff DR; Department of Surgery and Cancer, Imperial College London, London, UK.
Ann Surg Oncol ; 28(7): 3751-3760, 2021 Jul.
Article en En | MEDLINE | ID: mdl-33165721
ABSTRACT

PURPOSE:

To calculate the diagnostic accuracy of nipple aspirate fluid (NAF) cytology.

BACKGROUND:

Evaluation of NAF cytology in asymptomatic patients conceptually offers a non-invasive method for either screening for breast cancer or else predicting or stratifying future cancer risk.

METHODS:

Studies were identified by performing electronic searches up to August 2019. A meta-analysis was conducted to attain an overall pooled sensitivity and specificity of NAF for breast cancer detection.

RESULTS:

A search through 938 studies yielded a total of 19 studies. Overall, 9308 patients were examined, with cytology results from 10,147 breasts [age (years), mean ± SD = 49.73 ± 4.09 years]. Diagnostic accuracy meta-analysis of NAF revealed a pooled specificity of 0.97 (95% CI 0.97-0.98), and sensitivity of 0.64 (95% CI 0.62-0.66).

CONCLUSIONS:

The diagnostic accuracy of nipple smear cytology is limited by poor sensitivity. If nipple fluid assessment is to be used for diagnosis, then emerging technologies for fluid biomarker analysis must supersede the current diagnostic accuracy of NAF cytology.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Líquido Aspirado del Pezón Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Female / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Líquido Aspirado del Pezón Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Female / Humans Idioma: En Año: 2021 Tipo del documento: Article