An autopsy case of severe acute pancreatitis induced by administration of pazopanib following nivolumab.
Pancreatology
; 21(1): 21-24, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-33184007
ABSTRACT
Drug-induced pancreatitis is often mild to moderate in severity, but severe and even fatal cases can occur. Here, we report a 74-year-old woman undergoing chemotherapy for recurrent renal cell carcinoma, who presented with abdominal pain after administration of pazopanib following nivolumab and was diagnosed with severe acute pancreatitis. Administration of methylprednisolone and conservative treatment were initiated, but clinical findings and laboratory tests rapidly worsened. When she died, an autopsy was performed. The autopsy findings suggested the possibility of pancreatitis as immune-related adverse events. To the best of our knowledge, no fatal cases of acute pancreatitis due to nivolumab or pazopanib have been reported. We considered that the effects of nivolumab were sustained in the pancreas, and pazopanib administration might have worsened the toxicity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pancreatitis
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Pirimidinas
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Sulfonamidas
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Nivolumab
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Indazoles
Límite:
Aged
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Female
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article