Chromatin Tracing: Imaging 3D Genome and Nucleome.

Hu, Mengwei; Wang, Siyuan

Hu, Mengwei; Wang, Siyuan.

Hu M; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Wang S; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA; Yale Combined Program in the Biological and Biomedical Sciences, Yale University, New Haven, CT, USA; Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA; Biochemistry, Quantitative Biology, Biophysics, and Structural Biology Program, Yale University, New Haven, CT, USA; MD-PhD Program, Yale

Trends Cell Biol ; 31(1): 5-8, 2021 01.

Article en En | MEDLINE | ID: mdl-33191055

ABSTRACT

ABSTRACT

Correct 3D genome organization is essential for the proper functioning of the genome. Recent advances in image-based 3D genomics techniques have enabled direct tracing of chromatin folding and multiplexed imaging of nucleome architectures in single cells of several important biological systems. Here, we discuss these advances and the future directions of image-based 3D genomics.

Asunto(s)

Cromatina/metabolismo; Genoma; Imagenología Tridimensional; Animales; Genómica; Humanos; Transcriptoma/genética

Palabras clave

3D genome; chromatin folding; chromatin tracing; image-based spatial omics; multiplexed imaging of nucleome architectures; multiplexed sequential fluorescent in situ hybridization

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cromatina / Genoma / Imagenología Tridimensional Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

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