Syringe preparation technique and minor adverse reactions to diphtheria-tetanus-pertussis immunization.
Pediatr Infect Dis J
; 6(11): 1048-50, 1987 Nov.
Article
en En
| MEDLINE
| ID: mdl-3320932
ABSTRACT
Minor local reactions and subcutaneous abscesses following diphtheria, tetanus and pertussis immunization have been attributed to vaccine left in the subcutaneous needle path from vaccine coating the needle. Various syringe preparation techniques have therefore been advocated to prevent reactions. To evaluate these recommendations we compared rates of minor reactions in 200 children randomly assigned to one of three groups that differed only in the handling of the filled syringe in Group 1 the needle was changed before injection; in Group 2 the needle was wiped with sterile gauze before injection; in Group 3 the same needle was used to draw up and to inject the dose and was not wiped. Overall 27% of children had febrile (greater than 38 degrees C) reactions, 62% became fussy and 79% had a local reaction. Rates of reactions were nearly identical in the three groups, except that children in group 2 receiving their second dose or more of diphtheria-tetanus toxoid-pertussis vaccine were more likely to become febrile at greater than 38 degrees C (32%) or fussy (78%) (P less than 0.05 and P less than 0.02, respectively). We conclude that changing needles does not reduce the rate of minor local and systemic reactions. Wiping needles may increase the rate of reactions.
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Banco de datos:
MEDLINE
Asunto principal:
Jeringas
/
Toxoide Diftérico
/
Toxoide Tetánico
/
Vacuna contra la Tos Ferina
Tipo de estudio:
Clinical_trials
Límite:
Child
/
Child, preschool
/
Humans
/
Infant
Idioma:
En
Año:
1987
Tipo del documento:
Article