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The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.
Lebeau, Paul F; Wassef, Hanny; Byun, Jae Hyun; Platko, Khrystyna; Ason, Brandon; Jackson, Simon; Dobroff, Joshua; Shetterly, Susan; Richards, William G; Al-Hashimi, Ali A; Won, Kevin Doyoon; Mbikay, Majambu; Prat, Annik; Tang, An; Paré, Guillaume; Pasqualini, Renata; Seidah, Nabil G; Arap, Wadih; Chrétien, Michel; Austin, Richard C.
  • Lebeau PF; Department of Medicine, McMaster University, The Research Institute of St. Joe's Hamilton and Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.
  • Wassef H; Laboratory of Functional Endoproteolysis, Clinical Research Institute of Montreal, affiliated with the University of Montreal, Montreal, Quebec, Canada.
  • Byun JH; Department of Medicine, McMaster University, The Research Institute of St. Joe's Hamilton and Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.
  • Platko K; Department of Medicine, McMaster University, The Research Institute of St. Joe's Hamilton and Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.
  • Ason B; Cardiometabolic Disorders, Amgen Research Inc., South San Francisco, California, USA.
  • Jackson S; Cardiometabolic Disorders, Amgen Research Inc., South San Francisco, California, USA.
  • Dobroff J; Bristol Myers Squibb, Redwood City, California, USA.
  • Shetterly S; Cardiometabolic Disorders, Amgen Research Inc., South San Francisco, California, USA.
  • Richards WG; 23andMe, South San Francisco, California, USA.
  • Al-Hashimi AA; Department of Medicine, McMaster University, The Research Institute of St. Joe's Hamilton and Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.
  • Won KD; Department of Medicine, McMaster University, The Research Institute of St. Joe's Hamilton and Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.
  • Mbikay M; Laboratory of Functional Endoproteolysis, Clinical Research Institute of Montreal, affiliated with the University of Montreal, Montreal, Quebec, Canada.
  • Prat A; Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated with the University of Montreal, Montreal, Quebec, Canada.
  • Tang A; Department of Radiology at the Centre Hospitalier Universitaire de Montréal, University of Montreal, Montreal, Quebec, Canada.
  • Paré G; Population Health Research Institute and Departments of Medicine, Epidemiology, and Pathology, McMaster University, Hamilton, Ontario, Canada.
  • Pasqualini R; Division of Cancer Biology, Department of Radiology Oncology, and.
  • Seidah NG; Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated with the University of Montreal, Montreal, Quebec, Canada.
  • Arap W; Division of Hematology/Oncology, Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, Newark, New Jersey, USA.
  • Chrétien M; Laboratory of Functional Endoproteolysis, Clinical Research Institute of Montreal, affiliated with the University of Montreal, Montreal, Quebec, Canada.
  • Austin RC; Department of Medicine, McMaster University, The Research Institute of St. Joe's Hamilton and Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.
J Clin Invest ; 131(2)2021 01 19.
Article en En | MEDLINE | ID: mdl-33211673
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Retículo Endoplásmico / Estrés del Retículo Endoplásmico / Proproteína Convertasa 9 / Mutación con Pérdida de Función / Proteínas de Choque Térmico / Hígado / Hepatopatías Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Retículo Endoplásmico / Estrés del Retículo Endoplásmico / Proproteína Convertasa 9 / Mutación con Pérdida de Función / Proteínas de Choque Térmico / Hígado / Hepatopatías Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article