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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial.
Ramasamy, Maheshi N; Minassian, Angela M; Ewer, Katie J; Flaxman, Amy L; Folegatti, Pedro M; Owens, Daniel R; Voysey, Merryn; Aley, Parvinder K; Angus, Brian; Babbage, Gavin; Belij-Rammerstorfer, Sandra; Berry, Lisa; Bibi, Sagida; Bittaye, Mustapha; Cathie, Katrina; Chappell, Harry; Charlton, Sue; Cicconi, Paola; Clutterbuck, Elizabeth A; Colin-Jones, Rachel; Dold, Christina; Emary, Katherine R W; Fedosyuk, Sofiya; Fuskova, Michelle; Gbesemete, Diane; Green, Catherine; Hallis, Bassam; Hou, Mimi M; Jenkin, Daniel; Joe, Carina C D; Kelly, Elizabeth J; Kerridge, Simon; Lawrie, Alison M; Lelliott, Alice; Lwin, May N; Makinson, Rebecca; Marchevsky, Natalie G; Mujadidi, Yama; Munro, Alasdair P S; Pacurar, Mihaela; Plested, Emma; Rand, Jade; Rawlinson, Thomas; Rhead, Sarah; Robinson, Hannah; Ritchie, Adam J; Ross-Russell, Amy L; Saich, Stephen; Singh, Nisha; Smith, Catherine C.
  • Ramasamy MN; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. Electronic address: maheshi.ramasamy@paediatrics.ox.ac.uk.
  • Minassian AM; The Jenner Institute, University of Oxford, Oxford, UK.
  • Ewer KJ; The Jenner Institute, University of Oxford, Oxford, UK.
  • Flaxman AL; The Jenner Institute, University of Oxford, Oxford, UK.
  • Folegatti PM; The Jenner Institute, University of Oxford, Oxford, UK.
  • Owens DR; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Voysey M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Angus B; The Jenner Institute, University of Oxford, Oxford, UK.
  • Babbage G; The Jenner Institute, University of Oxford, Oxford, UK.
  • Belij-Rammerstorfer S; The Jenner Institute, University of Oxford, Oxford, UK.
  • Berry L; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Bibi S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Bittaye M; The Jenner Institute, University of Oxford, Oxford, UK.
  • Cathie K; Paediatric Medicine, University of Southampton, Southampton, UK.
  • Chappell H; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Charlton S; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Cicconi P; The Jenner Institute, University of Oxford, Oxford, UK.
  • Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Colin-Jones R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Dold C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Emary KRW; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Fedosyuk S; The Jenner Institute, University of Oxford, Oxford, UK.
  • Fuskova M; The Jenner Institute, University of Oxford, Oxford, UK.
  • Gbesemete D; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Green C; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK.
  • Hallis B; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Hou MM; The Jenner Institute, University of Oxford, Oxford, UK.
  • Jenkin D; The Jenner Institute, University of Oxford, Oxford, UK.
  • Joe CCD; The Jenner Institute, University of Oxford, Oxford, UK.
  • Kelly EJ; AstraZeneca BioPharmaceuticals Research and Development, Washington, DC, USA.
  • Kerridge S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Lawrie AM; The Jenner Institute, University of Oxford, Oxford, UK.
  • Lelliott A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Lwin MN; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Makinson R; The Jenner Institute, University of Oxford, Oxford, UK.
  • Marchevsky NG; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Mujadidi Y; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Munro APS; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Pacurar M; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Plested E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Rand J; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Rawlinson T; The Jenner Institute, University of Oxford, Oxford, UK.
  • Rhead S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Robinson H; Nuffield Department of Medicine, and Oxford Centre for Clinical Tropical Medicine and Global Health, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Ritchie AJ; The Jenner Institute, University of Oxford, Oxford, UK.
  • Ross-Russell AL; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Saich S; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK.
  • Singh N; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Smith CC; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Lancet ; 396(10267): 1979-1993, 2021 12 19.
Article en En | MEDLINE | ID: mdl-33220855
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunogenicidad Vacunal / Vacunas contra la COVID-19 Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunogenicidad Vacunal / Vacunas contra la COVID-19 Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2021 Tipo del documento: Article