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Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).
Ho, Joseph D; Lee, Matthew R; Rauch, Charles T; Aznavour, Kristen; Park, Jonathan S; Luz, John G; Antonysamy, Stephen; Condon, Bradley; Maletic, Milan; Zhang, Aiping; Hickey, Michael J; Hughes, Norman E; Chandrasekhar, Srinivasan; Sloan, Ashley V; Gooding, Karen; Harvey, Anita; Yu, Xiao-Peng; Kahl, Steven D; Norman, Bryan H.
  • Ho JD; Lilly Biotechnology Center, San Diego, CA 92121, USA. Electronic address: ho_joseph_d@lilly.com.
  • Lee MR; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Rauch CT; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Aznavour K; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Park JS; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Luz JG; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Antonysamy S; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Condon B; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Maletic M; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Zhang A; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Hickey MJ; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Hughes NE; Lilly Biotechnology Center, San Diego, CA 92121, USA.
  • Chandrasekhar S; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
  • Sloan AV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
  • Gooding K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
  • Harvey A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
  • Yu XP; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
  • Kahl SD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
  • Norman BH; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. Electronic address: bryan.norman@envedabio.com.
Biochim Biophys Acta Gen Subj ; 1865(2): 129800, 2021 02.
Article en En | MEDLINE | ID: mdl-33246032
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Eicosanoides / Inhibidores Enzimáticos / Descubrimiento de Drogas / Inhibidores de Proteína Activante de 5-Lipoxigenasa / Prostaglandina-E Sintasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Eicosanoides / Inhibidores Enzimáticos / Descubrimiento de Drogas / Inhibidores de Proteína Activante de 5-Lipoxigenasa / Prostaglandina-E Sintasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article