Potential role of the gut microbiota in neuromyelitis optica spectrum disorder: Implication for intervention.
J Clin Neurosci
; 82(Pt B): 193-199, 2020 Dec.
Article
en En
| MEDLINE
| ID: mdl-33257156
ABSTRACT
The gut microbiota plays an important role in the occurrence and development of neuroimmunological diseases. Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system that is characterized by the peripheral production of the disease-specific serum autoantibody aquaporin-4 (AQP4)-IgG. Recently, accumulating evidence has provided insights into the associations of gut microbiota dysbiosis and intestinal mucosal barrier destruction with NMOSD, but the underlying pathogenesis remains unclear. Thus, a microbiota intervention might be a potential therapeutic strategy for NMOSD by regulating the gut microbiota, repairing the intestinal mucosal barrier, and modulating intestinal immunity and peripheral immunity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neuromielitis Óptica
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Disbiosis
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Microbioma Gastrointestinal
Límite:
Female
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Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article