Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway.

Dong, Jian-Yi; Xia, Kai-Jun; Liang, Wei; Liu, Lu-Lu; Yang, Fang; Fang, Xue-Sheng; Xiong, Yong-Jian; Wang, Liang; Zhou, Zi-Juan; Li, Chang-Yi; Zhang, Wei-Dong; Wang, Jing-Yu; Chen, Da-Peng

Dong, Jian-Yi; Xia, Kai-Jun; Liang, Wei; Liu, Lu-Lu; Yang, Fang; Fang, Xue-Sheng; Xiong, Yong-Jian; Wang, Liang; Zhou, Zi-Juan; Li, Chang-Yi; Zhang, Wei-Dong; Wang, Jing-Yu; Chen, Da-Peng.

Dong JY; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Xia KJ; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Liang W; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Liu LL; Physiology, Dalian Medical University, Dalian, 116044, China.
Yang F; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Fang XS; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Xiong YJ; Central Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, 116044, China.
Wang L; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Zhou ZJ; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Li CY; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Zhang WD; Compartive Medicine, Dalian Medical University, Dalian, 116044, China.
Wang JY; Laboratory Animal Center, Dalian Medical University, Dalian, 116044, China. wangjingyus@163.com.
Chen DP; Compartive Medicine, Dalian Medical University, Dalian, 116044, China. cdp.9527@163.com.

Acta Pharmacol Sin ; 42(9): 1461-1471, 2021 Sep.

Article en En | MEDLINE | ID: mdl-33268823

Asunto(s)

Colitis/tratamiento farmacológico; Retículo Endoplásmico/metabolismo; Ginsenósidos/farmacología; Ubiquitina-Proteína Ligasas/metabolismo; Animales; Apoptosis/efectos de los fármacos; Línea Celular; Colitis/inducido químicamente; Colitis/patología; Colon/metabolismo; Citocinas/metabolismo; Sulfato de Dextran; Humanos; Ratones; Ratones Endogámicos C57BL; Transducción de Señal/efectos de los fármacos; Sulfasalazina/farmacología

Palabras clave

DSS; ER stress; Fas; Hrd1; TNBS; apoptosis; epithelium; ginsenoside Rb1; inflammatory bowel disease; sulfasalazine

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Colitis / Ginsenósidos / Ubiquitina-Proteína Ligasas / Retículo Endoplásmico Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

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