Ultrahypofractionation of localized prostate cancer : Statement from the DEGRO working group prostate cancer.
Strahlenther Onkol
; 197(2): 89-96, 2021 Feb.
Article
en En
| MEDLINE
| ID: mdl-33301049
ABSTRACT
Due to its low fractionation sensitivity, also known as "alpha/beta ratio," in relation to its surrounding organs at risk, prostate cancer is predestined for hypofractionated radiation schedules assuming an increased therapeutic ratio compared to normofractionated regimens. While moderate hypofractionation (2.2-4â¯Gy) has been proven to be non-inferior to normal fractionation in several large randomized trials for localized prostate cancer, level I evidence for ultrahypofractionation (>4â¯Gy) was lacking until recently. An accumulating body of non-randomized evidence has recently been strengthened by the publication of two randomized studies comparing ultrahypofractionation with a normofractionated schedule, i.e., the Scandinavian HYPO-RT trial by Widmark et al. and the first toxicity results of the PACEB trial. In this review, we aim to give a brief overview of the current evidence of ultrahypofractionation, make an overall assessment of the level of evidence, and provide recommendations and requirements that should be followed before introducing ultrahypofractionation into routine clinical use.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Hipofraccionamiento de la Dosis de Radiación
Tipo de estudio:
Clinical_trials
/
Guideline
Límite:
Humans
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Male
Idioma:
En
Año:
2021
Tipo del documento:
Article