Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.

Yan, Bo; Ai, Youwei; Sun, Qi; Ma, Yan; Cao, Yang; Wang, Jiawen; Zhang, Zhiyuan; Wang, Xiaodong

Yan, Bo; Ai, Youwei; Sun, Qi; Ma, Yan; Cao, Yang; Wang, Jiawen; Zhang, Zhiyuan; Wang, Xiaodong.

Yan B; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China. Electronic address: yanbo@nibs.ac.cn.
Ai Y; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China. Electronic address: aiyouwei@nibs.ac.cn.
Sun Q; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China.
Ma Y; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.
Cao Y; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.
Wang J; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.
Zhang Z; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.
Wang X; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.

Mol Cell ; 81(2): 355-369.e10, 2021 01 21.

Article en En | MEDLINE | ID: mdl-33321093

Asunto(s)

Membrana Celular/química; Sistema Enzimático del Citocromo P-450/genética; Citocromo-B(5) Reductasa/genética; Ácidos Grasos Insaturados/metabolismo; Ferroptosis/genética; NADP/metabolismo; Animales; Línea Celular Tumoral; Membrana Celular/efectos de los fármacos; Membrana Celular/metabolismo; Concanavalina A/farmacología; Sistema Enzimático del Citocromo P-450/deficiencia; Citocromo-B(5) Reductasa/deficiencia; Transporte de Electrón/efectos de los fármacos; Ferroptosis/efectos de los fármacos; Células HEK293; Células HeLa; Humanos; Peróxido de Hidrógeno/metabolismo; Peroxidación de Lípido/efectos de los fármacos; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Ratones Desnudos; Oxígeno/metabolismo; Compuestos de Fenilurea/farmacología; Piperazinas/farmacología; Piridinas/farmacología; Sorafenib/farmacología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Membrana Celular / Sistema Enzimático del Citocromo P-450 / Citocromo-B(5) Reductasa / Ácidos Grasos Insaturados / Ferroptosis / NADP Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

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