Expression of APOBEC family members as regulators of endogenous retroelements and malignant transformation in systemic autoimmunity.
Clin Immunol
; 223: 108649, 2021 02.
Article
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| MEDLINE
| ID: mdl-33326823
ABSTRACT
OBJECTIVE:
To explore whether APOBEC family members are involved in the response to inappropriate expression of L1 retroelements in primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), as well as in SS related lymphomagenesis.METHODS:
Minor salivary glands (MSG) and kidney biopsy (KB) specimens were obtained from 41 SS patients (10 with lymphoma) and 23 patients with SLE, respectively. PBMC and sera were also collected from 73 SLE patients. Full-length L1 transcripts, members of the APOBEC and IFN family were quantitated by real time PCR. Type I IFN activity was assessed in lupus plasma by a cell assay.RESULTS:
APOBEC3A was increased in SS MSG, SLE KB and PBMC and correlated with L1. AID and APOBEC3G were particularly overexpressed in MSG tissues derived from SS lymphoma patients.CONCLUSION:
These data reveal a previously unappreciated role of APOBEC family proteins in the pathogenesis of systemic autoimmunity and SS related lymphomagenesis.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Glándulas Salivales
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Leucocitos Mononucleares
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Proteínas
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Síndrome de Sjögren
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Retrovirus Endógenos
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Citidina Desaminasa
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Riñón
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Lupus Eritematoso Sistémico
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Linfoma
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article