Chronic Enteropathy Associated with SLCO2A1 with Pachydermoperiostosis.
Intern Med
; 59(24): 3147-3154, 2020.
Article
en En
| MEDLINE
| ID: mdl-33328413
ABSTRACT
A 49-year-old man complained of chronic palpitation and shortness of breath, which had recently become exacerbated. A blood examination indicated severe refractory anemia and hypoproteinemia. Physical examinations revealed anemia, a systolic murmur, and spoon nails. Multiple nonspecific ileal ulcers were observed. A pathological examination indicated a small granuloma with CD68-positive histiocytes. He had a deeply wrinkled forehead, chiseled face, and clubbed fingers. Radiography revealed periostosis of the fingers and long bones in the limb. He was diagnosed with pachydermoperiostosis. SLCO2A1 demonstrated a c.1807C>T homo-mutation. He was also diagnosed with SLCO2A1-associated chronic enteropathy and thus was treated with 5-aminosalicylic acid, which temporarily improved the ileal ulcers, anemia, and hypoalbuminemia.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Osteoartropatía Hipertrófica Primaria
/
Enfermedades Inflamatorias del Intestino
/
Transportadores de Anión Orgánico
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Año:
2020
Tipo del documento:
Article