Massive gingival bleed: a rare manifestation of cyclosporine toxicity.
BMJ Case Rep
; 13(12)2020 Dec 22.
Article
en En
| MEDLINE
| ID: mdl-33370971
ABSTRACT
A 12-year-old patient of thalassaemia major developed autoimmune cytopaenia after undergoing haematopoietic stem cell transplantation. She was started on cyclosporine (CsA) in view of poor response to steroids. She developed CsA toxicity manifesting as gum hyperplasia with multiple episodes of gum bleed. During endotracheal intubation for an elective splenectomy, she developed significant bleeding from gums requiring massive transfusion. Postoperatively the gum bleed persisted even after embolisation of facial artery and multiple transfusions. The catastrophic sequelae include transfusion-related lung injury, acute circulatory failure with subsequent cardiac arrest and death. Gum hyperplasia is a commonly reported toxic effect of CsA. Lethal presentations of this toxicity with such severity are limited in the medical literature. Evaluation of the patient's medical and laboratory records, along with a review of literature, was very helpful in understanding more about the toxicity of CsA.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hemorragia Gingival
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Ciclosporina
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Lesión Pulmonar Aguda Postransfusional
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Hiperplasia Gingival
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Paro Cardíaco
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Inmunosupresores
Tipo de estudio:
Etiology_studies
Límite:
Child
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Female
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Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article