A stem cell based <i>in vitro</i> model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.

Graffmann, Nina; Ncube, Audrey; Martins, Soraia; Fiszl, Aurelian Robert; Reuther, Philipp; Bohndorf, Martina; Wruck, Wasco; Beller, Mathias; Czekelius, Constantin; Adjaye, James

A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.

Graffmann, Nina; Ncube, Audrey; Martins, Soraia; Fiszl, Aurelian Robert; Reuther, Philipp; Bohndorf, Martina; Wruck, Wasco; Beller, Mathias; Czekelius, Constantin; Adjaye, James.

Graffmann N; Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Düsseldorf, Medical faculty, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Ncube A; Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Düsseldorf, Medical faculty, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Martins S; Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Düsseldorf, Medical faculty, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Fiszl AR; Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Düsseldorf, Medical faculty, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Reuther P; Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine University Düsseldorf 40225, Düsseldorf, Germany.
Bohndorf M; Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Düsseldorf, Medical faculty, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Wruck W; Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Düsseldorf, Medical faculty, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Beller M; Institute for Mathematical Modeling of Biological Systems, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Czekelius C; Systems Biology of Lipid Metabolism, Heinrich-Heine University Düsseldorf 40225, Düsseldorf, Germany.
Adjaye J; Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine University Düsseldorf 40225, Düsseldorf, Germany.

Biol Open ; 10(1)2021 01 25.

Article en En | MEDLINE | ID: mdl-33372064

Asunto(s)

Adaptación Biológica; Dieta Alta en Grasa; Metabolismo Energético; Enfermedad del Hígado Graso no Alcohólico/etiología; Enfermedad del Hígado Graso no Alcohólico/metabolismo; Piperidinas/farmacología; Células Madre/metabolismo; Adiponectina/metabolismo; Biomarcadores; Diferenciación Celular; Células Cultivadas; Regulación de la Expresión Génica; Gluconeogénesis; Hepatocitos/metabolismo; Humanos; Células Madre Pluripotentes Inducidas/citología; Células Madre Pluripotentes Inducidas/metabolismo; Metabolismo de los Lípidos; Enfermedad del Hígado Graso no Alcohólico/patología; Piperidinas/uso terapéutico; Transducción de Señal

Palabras clave

AdipoRon; FGF21; Hepatocyte differentiation; Hepatocyte-like cells; Metabolism; NAFLD

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Células Madre / Adaptación Biológica / Metabolismo Energético / Dieta Alta en Grasa / Enfermedad del Hígado Graso no Alcohólico Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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