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The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis.
Liu, Jin; Weiling, Gu; Xueqin, Li; Liang, Xie; Linhong, Wang; Zhongwen, Chen.
  • Liu J; Department of Control and Prevention of Chronic Non-communicable Diseases, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, 314050, China.
  • Weiling G; Office, Jiaxing Center for Disease Control and Prevention, No.486 Wenqiao Road, Jiaxing, Zhejiang, 314050, China.
  • Xueqin L; Department of Control and Prevention of Chronic Non-communicable Diseases, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, 314050, China.
  • Liang X; Department of Control and Prevention of Chronic Non-communicable Diseases, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, 314050, China.
  • Linhong W; Department of Control and Prevention of Chronic Non-communicable Diseases, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, 314050, China.
  • Zhongwen C; Office, Jiaxing Center for Disease Control and Prevention, No.486 Wenqiao Road, Jiaxing, Zhejiang, 314050, China. chenzhongww21@163.com.
Environ Health Prev Med ; 26(1): 2, 2021 Jan 04.
Article en En | MEDLINE | ID: mdl-33397280
ABSTRACT

OBJECTIVES:

We performed an updated meta-analysis to clarify the relationship between the CEBPE rs2239633 polymorphism and the childhood acute lymphoblastic leukemia (CALL) susceptibility.

METHODS:

All the case-control studies were updated on October 5, 2020, through Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) electronic database. The heterogeneity in the study was tested by the Q test and I2, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI). We also performed sensitivity analysis to estimate the impact of individual studies on aggregate estimates. Publication bias was investigated by using funnel plot and Egger's regression test. All statistical analyses were performed using Stata 12.0.

RESULTS:

A total of 20 case-control studies were selected, including 7014 patients and 16,428 controls. There was no association of CEBPE rs2239633 polymorphism with CALL (CC vs CT + TT OR = 1.08, 95% CI = 0.94-1.26; CC + CT vs TT OR = 1.10, 95% CI = 0.94-1.30; C vs T OR = 1.02, 95% CI = 0.92-1.13). In the subgroup analysis by ethnicity, there is no significant association of this polymorphism and CALL risks among Asian and Caucasian populations in the three genetic models (CC vs CT + TT, CC + CT vs TT, and C vs T).

CONCLUSION:

This meta-analysis found no significant association between the CEBPE rs2239633 polymorphism and susceptibility to CALL.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Proteínas Potenciadoras de Unión a CCAAT / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Proteínas Potenciadoras de Unión a CCAAT / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Año: 2021 Tipo del documento: Article