The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice.

Shizu, Ryota; Ishimura, Mai; Nobusawa, Sumihito; Hosaka, Takuomi; Sasaki, Takamitsu; Kakizaki, Satoru; Yoshinari, Kouichi

Shizu, Ryota; Ishimura, Mai; Nobusawa, Sumihito; Hosaka, Takuomi; Sasaki, Takamitsu; Kakizaki, Satoru; Yoshinari, Kouichi.

Shizu R; Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Ishimura M; Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Nobusawa S; Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Hosaka T; Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Sasaki T; Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Kakizaki S; Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Yoshinari K; Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. yoshinari@u-shizuoka-ken.ac.jp.

Arch Toxicol ; 95(3): 1089-1102, 2021 03.

Article en En | MEDLINE | ID: mdl-33398415

Asunto(s)

Neoplasias Hepáticas/inducido químicamente; Fenobarbital/farmacología; Receptor X de Pregnano/efectos de los fármacos; Carbonitrilo de Pregnenolona/farmacología; Animales; Carcinogénesis/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Receptor de Androstano Constitutivo; Hepatocitos/efectos de los fármacos; Hígado/efectos de los fármacos; Hígado/patología; Neoplasias Hepáticas/patología; Masculino; Ratones; Ratones Endogámicos C3H; Receptor X de Pregnano/metabolismo; Receptores Citoplasmáticos y Nucleares/efectos de los fármacos; Receptores Citoplasmáticos y Nucleares/metabolismo; Análisis de Secuencia de ARN; Factores de Tiempo

Palabras clave

Chemical carcinogenesis; Epithelialmesenchymal transition; Hepatocellular carcinoma; Nuclear receptor; Transcriptome

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenobarbital / Carbonitrilo de Pregnenolona / Receptor X de Pregnano / Neoplasias Hepáticas Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article

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