Long-term Oncologic Outcomes of 1188 Tis-T2 Glottic Cancers Treated by Transoral Laser Microsurgery.
Otolaryngol Head Neck Surg
; 165(2): 321-328, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-33400625
ABSTRACT
OBJECTIVE:
To evaluate long-term disease-specific survival (DSS) and organ preservation (OP) rates in patients affected by Tis-T2 glottic squamous cell carcinoma (SCC) treated by carbon dioxide transoral laser microsurgery (CO2 TOLMS). STUDYDESIGN:
Single-center retrospective cohort study.SETTING:
Tertiary academic hospital.METHODS:
The study included patients treated by CO2 TOLMS for Tis-T2 glottic SCC at the Department of Otorhinolaryngology-Head and Neck Surgery of the University of Brescia, Italy, from 1988 to 2018. The malefemale ratio was 11.21, and the mean age was 64 years (range, 31-95). T categories were distributed as follows 124 (10%) Tis, 646 (54%) T1a, 172 (15%) T1b, and 246 (21%) T2.RESULTS:
Ten- and 20-year DSS rates were 97.6% and 96.3%, respectively, and 10- and 20-year OP rates were 94.7% and 93%. During the follow-up, 91% of patients were treated by CO2 TOLMS alone, while the remaining needed adjunctive treatments. Assessing the impact of multiple sessions of CO2 TOLMS, DSS showed no significant difference in terms of patients treated by 1, 2, or >2 procedures. Conversely, patients treated by >2 sessions of CO2 TOLMS showed a significantly worse OP rate.CONCLUSIONS:
Our series validates CO2 TOLMS as a long-term treatment strategy for early glottic SCC. Salvage CO2 TOLMS provided optimal results in terms of DSS and OP in patients with recurrence after previous transoral surgery.Palabras clave
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
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Neoplasias Laríngeas
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Terapia por Láser
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Láseres de Gas
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Glotis
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Microcirugia
Tipo de estudio:
Observational_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2021
Tipo del documento:
Article