A Novel Second-Generation EP2 Receptor Antagonist Reduces Neuroinflammation and Gliosis After Status Epilepticus in Rats.

Rojas, Asheebo; Amaradhi, Radhika; Banik, Avijit; Jiang, Chunxiang; Abreu-Melon, JuanMartin; Wang, Sarah; Dingledine, Raymond; Ganesh, Thota

Rojas, Asheebo; Amaradhi, Radhika; Banik, Avijit; Jiang, Chunxiang; Abreu-Melon, JuanMartin; Wang, Sarah; Dingledine, Raymond; Ganesh, Thota.

Rojas A; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA, 30322, USA. arajas@emory.edu.
Amaradhi R; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA, 30322, USA.
Banik A; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA, 30322, USA.
Jiang C; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA, 30322, USA.
Abreu-Melon J; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA, 30322, USA.
Wang S; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA, 30322, USA.
Dingledine R; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA, 30322, USA.
Ganesh T; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA, 30322, USA. tganesh@emory.edu.

Neurotherapeutics ; 18(2): 1207-1225, 2021 04.

Article en En | MEDLINE | ID: mdl-33410110

Asunto(s)

Gliosis/tratamiento farmacológico; Mediadores de Inflamación/antagonistas & inhibidores; Antagonistas de Prostaglandina/uso terapéutico; Subtipo EP2 de Receptores de Prostaglandina E/antagonistas & inhibidores; Estado Epiléptico/tratamiento farmacológico; Animales; Línea Celular; Relación Dosis-Respuesta a Droga; Gliosis/metabolismo; Humanos; Mediadores de Inflamación/metabolismo; Masculino; Ratones; Enfermedades Neuroinflamatorias/tratamiento farmacológico; Enfermedades Neuroinflamatorias/metabolismo; Pilocarpina/toxicidad; Antagonistas de Prostaglandina/farmacología; Ratas; Ratas Sprague-Dawley; Subtipo EP2 de Receptores de Prostaglandina E/metabolismo; Estado Epiléptico/inducido químicamente; Estado Epiléptico/metabolismo

Palabras clave

BBB.; COX-2; EP2; PGE2; Pilocarpine; TG8-260; gliosis; hippocampus; inflammation; neurodegeneration; status epilepticus

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antagonistas de Prostaglandina / Estado Epiléptico / Mediadores de Inflamación / Subtipo EP2 de Receptores de Prostaglandina E / Gliosis Límite: Animals / Humans / Male Idioma: En Año: 2021 Tipo del documento: Article

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