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Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
Norheim, Frode; Chella Krishnan, Karthickeyan; Bjellaas, Thomas; Vergnes, Laurent; Pan, Calvin; Parks, Brian W; Meng, Yonghong; Lang, Jennifer; Ward, James A; Reue, Karen; Mehrabian, Margarete; Gundersen, Thomas E; Péterfy, Miklós; Dalen, Knut T; Drevon, Christian A; Hui, Simon T; Lusis, Aldons J; Seldin, Marcus M.
  • Norheim F; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
  • Chella Krishnan K; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Bjellaas T; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
  • Vergnes L; Vitas AS, Oslo, Norway.
  • Pan C; Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA.
  • Parks BW; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
  • Meng Y; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
  • Lang J; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
  • Ward JA; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
  • Reue K; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
  • Mehrabian M; Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA.
  • Gundersen TE; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
  • Péterfy M; Vitas AS, Oslo, Norway.
  • Dalen KT; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
  • Drevon CA; Depatrment of Basic Medical Sciences, Western University of Health Sciences, Pomona, CA, USA.
  • Hui ST; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Lusis AJ; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Seldin MM; Vitas AS, Oslo, Norway.
Mol Syst Biol ; 17(1): e9684, 2021 01.
Article en En | MEDLINE | ID: mdl-33417276
To elucidate the contributions of specific lipid species to metabolic traits, we integrated global hepatic lipid data with other omics measures and genetic data from a cohort of about 100 diverse inbred strains of mice fed a high-fat/high-sucrose diet for 8 weeks. Association mapping, correlation, structure analyses, and network modeling revealed pathways and genes underlying these interactions. In particular, our studies lead to the identification of Ifi203 and Map2k6 as regulators of hepatic phosphatidylcholine homeostasis and triacylglycerol accumulation, respectively. Our analyses highlight mechanisms for how genetic variation in hepatic lipidome can be linked to physiological and molecular phenotypes, such as microbiota composition.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Proteínas Nucleares / MAP Quinasa Quinasa 6 / Hígado Graso / Dieta Alta en Grasa / Glucosa Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Proteínas Nucleares / MAP Quinasa Quinasa 6 / Hígado Graso / Dieta Alta en Grasa / Glucosa Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article