Pharmacological and computer-aided studies provide new insights into <i>Millettia peguensis</i> Ali (Fabaceae).

Pharmacological and computer-aided studies provide new insights into Millettia peguensis Ali (Fabaceae).

Alam, Safaet; Emon, Nazim Uddin; Shahriar, Saimon; Richi, Fahmida Tasnim; Haque, Mohammad Rashedul; Islam, Mohammad Nazmul; Sakib, Shahenur Alam; Ganguly, Amlan.

Alam S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Emon NU; Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
Shahriar S; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Richi FT; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Haque MR; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Islam MN; Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
Sakib SA; Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
Ganguly A; Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

Saudi Pharm J ; 28(12): 1777-1790, 2020 Dec.

Article en En | MEDLINE | ID: mdl-33424267

Palabras clave

5-HT3, 5-hydroxytryptamine 3; ASA, acetyl salicylic acid; Analgesic; Antidiarrheal; Antioxidant; Antitumor; BHT, butylated hydroxytoluene; CADD, computer-aided drug discovery; COX 1, cyclooxygenase-1; COX 2, cyclooxygenase-2; DPPH, 2,2-diphenyl-1-picryl-hydrazyl-hydrate; GABA, gamma-Aminobutyric acid; IC50, half maximal inhibitory concentration; IL-1, interleukin-1; LC50, Lethal Concentration 50; MEMP, methanol extract of Millettia peguensis; MMP 9, matrix metalloproteinase 9; Millettia peguensis; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; RONS, reactive oxygen and nitrogen species; ROS, reactive oxygen species; TNF-alpha, tumour necrosis factor alpha