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CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.
Lenk, Lennart; Carlet, Michela; Vogiatzi, Fotini; Spory, Lea; Winterberg, Dorothee; Cousins, Antony; Vossen-Gajcy, Michaela; Ibruli, Olta; Vokuhl, Christian; Cario, Gunnar; El Ayoubi, Omar; Kramer, Lisa; Ritgen, Matthias; Brüggemann, Monika; Häsler, Robert; Schrappe, Martin; Fuhrmann, Stephan; Halsey, Christina; Jeremias, Irmela; Hobeika, Elias; Jumaa, Hassan; Alsadeq, Ameera; Schewe, Denis M.
  • Lenk L; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
  • Carlet M; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), Marchioninistraße 25, 81377, Munich, Germany.
  • Vogiatzi F; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
  • Spory L; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
  • Winterberg D; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
  • Cousins A; Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1QH, UK.
  • Vossen-Gajcy M; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
  • Ibruli O; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
  • Vokuhl C; Department of Pathology, Section of Pediatric Pathology, Venusberg-Campus 1, Gebäude 62, 53127, Bonn, Germany.
  • Cario G; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
  • El Ayoubi O; Institute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
  • Kramer L; Institute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
  • Ritgen M; Department of Medicine II, University Hospital Schleswig-Holstein, Langer Segen 8-10, 24105, Kiel, Germany.
  • Brüggemann M; Department of Medicine II, University Hospital Schleswig-Holstein, Langer Segen 8-10, 24105, Kiel, Germany.
  • Häsler R; Institute of Clinical Molecular Biology, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Campus Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
  • Schrappe M; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
  • Fuhrmann S; Department of Hematology and Oncology, HELIOS Hospital Berlin-Buch, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
  • Halsey C; Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1QH, UK.
  • Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), Marchioninistraße 25, 81377, Munich, Germany.
  • Hobeika E; German Cancer Consortium (DKTK), Partnering Site Munich, Pettenkoferstr. 8a, 80336, München, Germany.
  • Jumaa H; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Lindwurmstraße 4, 80337, München, Germany.
  • Alsadeq A; Institute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
  • Schewe DM; Institute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Commun Biol ; 4(1): 73, 2021 01 15.
Article en En | MEDLINE | ID: mdl-33452446
ABSTRACT
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Neoplasias del Sistema Nervioso Central / Familia-src Quinasas / Antígenos CD79 Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Neoplasias del Sistema Nervioso Central / Familia-src Quinasas / Antígenos CD79 Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article