CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.
Commun Biol
; 4(1): 73, 2021 01 15.
Article
en En
| MEDLINE
| ID: mdl-33452446
ABSTRACT
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Leucemia-Linfoma Linfoblástico de Células Precursoras B
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Neoplasias del Sistema Nervioso Central
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Familia-src Quinasas
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Antígenos CD79
Límite:
Animals
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article