Bioactive amides from Polygonum cuspidatum.
J Asian Nat Prod Res
; 23(3): 228-234, 2021 Mar.
Article
en En
| MEDLINE
| ID: mdl-33459060
ABSTRACT
One pair of new amides enantiomers (1a and 1b) and two known amides were isolated from the rhizomes of Polygonum cuspidatum. Their structures were established using UV, IR, HRESIMS, and NMR data. Notably, compound 1 possesses unique C-C connection between feruloyltyramine and resveratrol. Their absolute configurations were determined by the ECD method. All compounds were evaluated for their α-glucosidase inhibitory activity and compounds 2 and 3 showed significant inhibitory activity with IC50 values of 2.82 and 13.06 µmol/L, respectively (positive control acarbose, IC50 385 µmol/L).
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polygonum
/
Fallopia japonica
Idioma:
En
Año:
2021
Tipo del documento:
Article