Melanin production in coelomycetous agents of black grain eumycetoma.
Trans R Soc Trop Med Hyg
; 115(4): 324-327, 2021 04 14.
Article
en En
| MEDLINE
| ID: mdl-33463687
ABSTRACT
BACKGROUND:
Eumycetoma is a fungal infection characterised by the formation of black grains by causative agents. The melanin biosynthetic pathways used by the most common causative agents of black-grain mycetoma are unknown and unravelling them could identify potential new therapeutic targets.METHOD:
Melanin biosynthetic pathways in the causative fungi were identified by the use of specific melanin inhibitors.RESULTS:
In Trematosphaeria grisea and Falciformispora tompkinsii, 1,8-dihydroxynaphthalene (DHN)-melanin synthesis was inhibited, while DHN-, 3,4-dihydroxyphenylalanine (DOPA)- and pyo-melanin were inhibited in Medicopsis romeroi and Falciformispora senegalensis.CONCLUSION:
Our data suggest that Me. romeroi and F. senegalensis synthesise DHN-, DOPA- and pyo-melanin, while T. grisea and F. tompkinsii only synthesise DHN-melanin.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Micetoma
Idioma:
En
Año:
2021
Tipo del documento:
Article