miR-34a in extracellular vesicles from bone marrow mesenchymal stem cells reduces rheumatoid arthritis inflammation via the cyclin I/ATM/ATR/p53 axis.

Wu, Huaiguo; Zhou, Xike; Wang, Xuedong; Cheng, Wei; Hu, Xinjia; Wang, Yueping; Luo, Bing; Huang, Wenjun; Gu, Juan

Wu, Huaiguo; Zhou, Xike; Wang, Xuedong; Cheng, Wei; Hu, Xinjia; Wang, Yueping; Luo, Bing; Huang, Wenjun; Gu, Juan.

Wu H; Center for Precision Medicine, Anhui No. 2 Provincial People's Hospital, Hefei, China.
Zhou X; Department of Medical Laboratory Science, The Fifth People's Hospital of Wuxi, Nanjing Medical University, Wuxi, China.
Wang X; Department of Pathology, The Fifth People's Hospital of Wuxi, The Medical School of Jiangnan University, Wuxi, China.
Cheng W; Center for Precision Medicine, Anhui No. 2 Provincial People's Hospital, Hefei, China.
Hu X; Department of Medical Laboratory Science, The Fifth People's Hospital of Wuxi, Nanjing Medical University, Wuxi, China.
Wang Y; Center for Precision Medicine, Anhui No. 2 Provincial People's Hospital, Hefei, China.
Luo B; Center for Precision Medicine, Anhui No. 2 Provincial People's Hospital, Hefei, China.
Huang W; Department of Osteoarthropathy, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University and the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.
Gu J; Center for Precision Medicine, Anhui No. 2 Provincial People's Hospital, Hefei, China.

J Cell Mol Med ; 25(4): 1896-1910, 2021 02.

Article en En | MEDLINE | ID: mdl-33465281

Asunto(s)

Artritis Reumatoide/genética; Artritis Reumatoide/metabolismo; Vesículas Extracelulares/metabolismo; Regulación de la Expresión Génica; Células Madre Mesenquimatosas/metabolismo; MicroARNs/genética; Transducción de Señal; Animales; Apoptosis/genética; Artritis Reumatoide/patología; Biomarcadores; Biopsia; Células Cultivadas; Ciclina I/metabolismo; Masculino; MicroARNs/metabolismo; Ratas; Sinoviocitos/metabolismo; Sinoviocitos/patología; Proteína p53 Supresora de Tumor/metabolismo

Palabras clave

ATM/ATR/p53 signalling pathway; Cyclin I; MicroRNA-34a; extracellular vesicles; inflammation; rheumatoid arthritis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Artritis Reumatoide / Transducción de Señal / Regulación de la Expresión Génica / MicroARNs / Células Madre Mesenquimatosas / Vesículas Extracelulares Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article

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