Emerging Roles of Protease-Activated Receptors (PARs) in the Modulation of Synaptic Transmission and Plasticity.
Int J Mol Sci
; 22(2)2021 Jan 16.
Article
en En
| MEDLINE
| ID: mdl-33467143
ABSTRACT
Protease-activated receptors (PARs) are a class of G protein-coupled receptors (GPCRs) with a unique mechanism of activation, prompted by a proteolytic cleavage in their N-terminal domain that uncovers a tethered ligand, which binds and stimulates the same receptor. PARs subtypes (PAR1-4) have well-documented roles in coagulation, hemostasis, and inflammation, and have been deeply investigated for their function in cellular survival/degeneration, while their roles in the brain in physiological conditions remain less appreciated. Here, we describe PARs' effects in the modulation of neurotransmission and synaptic plasticity. Available evidence, mainly concerning PAR1-mediated and PAR2-mediated regulation of glutamatergic and GABAergic transmission, supports that PARs are important modulators of synaptic efficacy and plasticity in normal conditions.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transmisión Sináptica
/
Receptores Proteinasa-Activados
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Plasticidad Neuronal
Límite:
Animals
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article