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Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates.
Lee, Hyun Myung; Andrys, Rudolf; Jonczyk, Jakub; Kim, Kyuneun; Vishakantegowda, Avinash G; Malinak, David; Skarka, Adam; Schmidt, Monika; Vaskova, Michaela; Latka, Kamil; Bajda, Marek; Jung, Young-Sik; Malawska, Barbara; Musilek, Kamil.
  • Lee HM; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
  • Andrys R; Department of Medicinal Chemistry and Pharmacology, Daejeon, Republic of Korea.
  • Jonczyk J; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Kim K; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
  • Vishakantegowda AG; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
  • Malinak D; Department of Medicinal Chemistry and Pharmacology, Daejeon, Republic of Korea.
  • Skarka A; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
  • Schmidt M; Department of Medicinal Chemistry and Pharmacology, Daejeon, Republic of Korea.
  • Vaskova M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Latka K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Bajda M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Jung YS; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
  • Malawska B; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
  • Musilek K; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
J Enzyme Inhib Med Chem ; 36(1): 437-449, 2021 Dec.
Article en En | MEDLINE | ID: mdl-33467931
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos de Piridinio / Compuestos de Quinolinio / Inhibidores de la Colinesterasa Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos de Piridinio / Compuestos de Quinolinio / Inhibidores de la Colinesterasa Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article