Single nucleotide polymorphisms in interleukin-6 attenuates hepatocytes injury in hypoxia/re-oxygenation via STAT3 signal pathway mediated autophagy.

Tang, Hongwei; Fang, Hongbo; Guo, Wenzhi; Cao, Shengli; Guo, Danfeng; Zhang, Huapeng; Gao, Jie; Zhang, Shuijun

Tang, Hongwei; Fang, Hongbo; Guo, Wenzhi; Cao, Shengli; Guo, Danfeng; Zhang, Huapeng; Gao, Jie; Zhang, Shuijun.

Tang H; Open and Key laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, Henan, People's Republic of China.
Fang H; ZhengZhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, People's Republic of China.
Guo W; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Cao S; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guo D; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhang H; Open and Key laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, Henan, People's Republic of China.
Gao J; ZhengZhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, People's Republic of China.
Zhang S; Open and Key laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, Henan, People's Republic of China.

Mol Biol Rep ; 48(2): 1687-1695, 2021 Feb.

Article en En | MEDLINE | ID: mdl-33484391

Asunto(s)

Apoptosis/genética; Autofagia/genética; Hepatocitos/metabolismo; Interleucina-6/genética; Interleucina-6/farmacología; Hígado/efectos de los fármacos; Daño por Reperfusión/metabolismo; Factor de Transcripción STAT3/metabolismo; Autofagia/efectos de los fármacos; Caspasa 3/genética; Caspasa 3/metabolismo; Hipoxia de la Célula/efectos de los fármacos; Hipoxia de la Célula/genética; Línea Celular; Supervivencia Celular/genética; Hepatocitos/efectos de los fármacos; Hepatocitos/patología; Humanos; Interleucina-6/metabolismo; Hígado/metabolismo; Hígado/patología; Polimorfismo de Nucleótido Simple; Proteínas Recombinantes; Daño por Reperfusión/genética; Factor de Transcripción STAT3/genética; Transducción de Señal/genética; Regulación hacia Arriba

Palabras clave

Autophagy; IL-6; Ischemia/reperfusion injury; STAT3 signaling pathway

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Daño por Reperfusión / Interleucina-6 / Apoptosis / Hepatocitos / Factor de Transcripción STAT3 / Hígado Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google