microRNA-21: a key modulator in oncogenic viral infections.
RNA Biol
; 18(5): 809-817, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33499700
ABSTRACT
Oncogenic viruses are associated with approximately 15% of human cancers. In viral infections, microRNAs play an important role in host-pathogen interactions. miR-21 is a highly conserved non-coding RNA that not only regulates the development of oncogenic viral diseases, but also responds to the regulation of intracellular signal pathways. Oncogenic viruses, including HBV, HCV, HPV, and EBV, co-evolve with their hosts and cause persistent infections. The upregulation of host miR-21 manipulates key cellular pathways to evade host immune responses and then promote viral replication. Thus, a better understanding of the role of miR-21 in viral infections may help us to develop effective genetically-engineered oncolytic virus-based therapies against cancer.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Virus Oncogénicos
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Infecciones Tumorales por Virus
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MicroARNs
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Interacciones Huésped-Patógeno
Límite:
Animals
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article