Differential estrogen-related responses in myofiber cross-sectional area of pelvic floor muscles in female rats.
Gynecol Endocrinol
; 37(6): 528-533, 2021 Jun.
Article
en En
| MEDLINE
| ID: mdl-33501865
ABSTRACT
OBJECTIVE:
To determine the role of estrogens in myofiber cross-sectional area (CSA) of the pubococcyegeus (Pcm) and iliococcygeus muscles (Icm).METHODS:
In Experiment 1, we excised the Pcm and Icm during the metestrus and proestrus stages of the estrous cycle to measure the myofiber CSA. In Experiment 2, we allocated other rats into the following groups sham (Sh), ovariectomized (OVX), OVX plus 1,4,6-androstatriene-3,17-dione (ATD; OVX + ATD), an aromatase inhibitor, and OVX plus estradiol benzoate (OVX + EB). We carried out appropriate statistical tests to determine significant differences (p ≤ 0.05) in variables measured for both Experiments.RESULTS:
The Pcm myofiber CSA at proestrus was higher than at metestrus, while the Icm myofiber CSA did not change. Ovariectomy increased the Pcm myofiber CSA, which was exacerbated with the ATD administration. The EB supplementation successfully reversed the ovariectomy-induced enlargement of the CSA. No significant changes were detected for the Icm myofiber CSA.CONCLUSIONS:
Fluctuating ovarian steroid levels at the estrus cycle significantly influence the CSA myofiber of the Pcm but not that of the Icm. Estrogen actions, having a gonadal or extragonadal origin, influence importantly the CSA of the Pcm.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Estradiol
/
Músculo Liso
/
Miofibrillas
Tipo de estudio:
Prevalence_studies
Límite:
Animals
Idioma:
En
Año:
2021
Tipo del documento:
Article