Connecting autoimmune disease to Bardet-Biedl syndrome and primary cilia.
EMBO Rep
; 22(2): e52180, 2021 02 03.
Article
en En
| MEDLINE
| ID: mdl-33511755
ABSTRACT
Bardet-Biedl syndrome (BBS) is a genetic disorder caused by the dysfunction of the primary cilium. To date, immunological defects in the disease have not been systematically assessed. In this issue, Tsyklauri and colleagues find, through detailed analysis of BBS mutant animals, that B-cell development is altered in mutant mice (Tsyklauri et al, 2021). The authors further report that BBS patients are more susceptible to autoimmune disorders. This study sheds new light on the potential role of primary cilia in controlling immune function in disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Síndrome de Bardet-Biedl
Límite:
Animals
/
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article