Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host.

Ribes, S; Zacke, L; Nessler, S; Saiepour, N; Avendaño-Guzmán, E; Ballüer, M; Hanisch, U K; Nau, R

Ribes, S; Zacke, L; Nessler, S; Saiepour, N; Avendaño-Guzmán, E; Ballüer, M; Hanisch, U K; Nau, R.

Ribes S; Institute of Neuropathology, University Medical Center, Georg August University Göttingen, Robert-Koch-Straße 40, D-37075, Göttingen, Germany. ribes.miravet@gmail.com.
Zacke L; Institute of Neuropathology, University Medical Center, Georg August University Göttingen, Robert-Koch-Straße 40, D-37075, Göttingen, Germany.
Nessler S; Institute of Neuropathology, University Medical Center, Georg August University Göttingen, Robert-Koch-Straße 40, D-37075, Göttingen, Germany.
Saiepour N; Institute of Neuropathology, University Medical Center, Georg August University Göttingen, Robert-Koch-Straße 40, D-37075, Göttingen, Germany.
Avendaño-Guzmán E; Institute of Neuropathology, University Medical Center, Georg August University Göttingen, Robert-Koch-Straße 40, D-37075, Göttingen, Germany.
Ballüer M; Institute of Neuropathology, University Medical Center, Georg August University Göttingen, Robert-Koch-Straße 40, D-37075, Göttingen, Germany.
Hanisch UK; Department of Geriatrics, Protestant Hospital Göttingen-Weende, Göttingen, Germany.
Nau R; Institute of Neuropathology, University Medical Center, Georg August University Göttingen, Robert-Koch-Straße 40, D-37075, Göttingen, Germany.

J Neuroinflammation ; 18(1): 39, 2021 Feb 02.

Article en En | MEDLINE | ID: mdl-33531028

Asunto(s)

Adyuvantes Inmunológicos/administración & dosificación; Inmunocompetencia/inmunología; Huésped Inmunocomprometido/inmunología; Meningitis Neumocócica/inmunología; Neutropenia/inmunología; Oligodesoxirribonucleótidos/administración & dosificación; Animales; Cerebelo/efectos de los fármacos; Cerebelo/inmunología; Cerebelo/metabolismo; Femenino; Inmunocompetencia/efectos de los fármacos; Huésped Inmunocomprometido/efectos de los fármacos; Inyecciones Intraventriculares; Masculino; Meningitis Neumocócica/tratamiento farmacológico; Meningitis Neumocócica/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Neutropenia/metabolismo; Neutropenia/prevención & control; Bazo/efectos de los fármacos; Bazo/inmunología; Bazo/metabolismo; Streptococcus pneumoniae; Resultado del Tratamiento

Palabras clave

Interleukin (IL)-12/IL-23p40; Macrophage inflammatory protein (MIP)-1α; Meningitis; Microglia; Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG ODN); Streptococcus pneumoniae; Toll-like receptor (TLR) 9

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligodesoxirribonucleótidos / Adyuvantes Inmunológicos / Huésped Inmunocomprometido / Inmunocompetencia / Meningitis Neumocócica / Neutropenia Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article

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