Endocrine toxicity of cancer immunotherapy: clinical challenges.
Endocr Connect
; 10(3): R116-R124, 2021 Mar.
Article
en En
| MEDLINE
| ID: mdl-33544091
ABSTRACT
Immune checkpoint inhibitors are now widely used in the treatment of multiple cancers. The major toxicities of these treatments are termed immune-related adverse events and endocrine dysfunction is common. Thyroid disease, hypopituitarism and a form of diabetes resembling type 1 diabetes are now all well described, with different patterns emerging with different checkpoint inhibitors. We review the presentation and management of the common endocrine immune-related adverse events, and discuss a number of recent advances in the understanding of these important, potentially life threatening toxicities. We also discuss some remaining dilemmas in management.
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2021
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Article