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Variation in predicted COVID-19 risk among lemurs and lorises.
Melin, Amanda D; Orkin, Joseph D; Janiak, Mareike C; Valenzuela, Alejandro; Kuderna, Lukas; Marrone, Frank; Ramangason, Hasinala; Horvath, Julie E; Roos, Christian; Kitchener, Andrew C; Khor, Chiea Chuen; Lim, Weng Khong; Lee, Jessica G H; Tan, Patrick; Umapathy, Govindhaswamy; Raveendran, Muthuswamy; Harris, R Alan; Gut, Ivo; Gut, Marta; Lizano, Esther; Nadler, Tilo; Zinner, Dietmar; Johnson, Steig E; Jarvis, Erich D; Fedrigo, Olivier; Wu, Dongdong; Zhang, Guojie; Farh, Kyle Kai-How; Rogers, Jeffrey; Marques-Bonet, Tomas; Navarro, Arcadi; Juan, David; Arora, Paramjit S; Higham, James P.
  • Melin AD; Department of Anthropology and Archaeology, University of Calgary, Canada.
  • Orkin JD; Department of Medical Genetics, University of Calgary, Canada.
  • Janiak MC; Alberta Children's Hospital Research Institute, University of Calgary, Canada.
  • Valenzuela A; Experimental and Health Sciences Department (DCEXS), Institut de Biologia Evolutiva, Universitat Pompeu Fabra-CSIC, Barcelona, Spain.
  • Kuderna L; School of Science, Engineering & Environment, University of Salford, United Kingdom.
  • Marrone F; Experimental and Health Sciences Department (DCEXS), Institut de Biologia Evolutiva, Universitat Pompeu Fabra-CSIC, Barcelona, Spain.
  • Ramangason H; Experimental and Health Sciences Department (DCEXS), Institut de Biologia Evolutiva, Universitat Pompeu Fabra-CSIC, Barcelona, Spain.
  • Horvath JE; Department of Chemistry, New York University, United States.
  • Roos C; Department of Anthropology and Archaeology, University of Calgary, Canada.
  • Kitchener AC; Genomics & Microbiology Research Laboratory, North Carolina Museum of Natural Sciences, Raleigh, NC, USA.
  • Khor CC; Department of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC, USA.
  • Lim WK; Department of Evolutionary Anthropology, Duke University, Durham, NC, USA.
  • Lee JGH; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
  • Tan P; Gene Bank of Primates and Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göettingen, Germany.
  • Umapathy G; Department of Natural Sciences, National Museums Scotland and School of Geosciences, University of Edinburgh, Edinburgh, United Kingdom.
  • Raveendran M; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
  • Harris RA; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Gut I; SingHealth Duke-NUS Institute of Precision Medicine, Singapore Health Services, Singapore.
  • Gut M; SingHealth Duke-NUS Genomic Medicine Centre, Singapore Health Services, Singapore.
  • Lizano E; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.
  • Nadler T; Department of Conservation, Research and Veterinary Services, Wildlife Reserves Singapore, Singapore.
  • Zinner D; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
  • Johnson SE; SingHealth Duke-NUS Institute of Precision Medicine, Singapore Health Services, Singapore.
  • Jarvis ED; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.
  • Fedrigo O; CSIR-Laboratory for the Conservation of Endangered Species, Centre for Cellular and Molecular Biology, Hyderabad, India.
  • Wu D; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States.
  • Zhang G; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States.
  • Farh KK; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Rogers J; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Marques-Bonet T; Experimental and Health Sciences Department (DCEXS), Institut de Biologia Evolutiva, Universitat Pompeu Fabra-CSIC, Barcelona, Spain.
  • Navarro A; Cuc Phuong Commune, Nho Quan District, Ninh Binh Province, Vietnam.
  • Juan D; Cognitive Ethology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.
  • Arora PS; Leibniz Science Campus Primate Cognition, Goettingen, Germany.
  • Higham JP; Department of Primate Cognition, Georg-August-University, Goettingen, Germany.
bioRxiv ; 2021 Feb 03.
Article en En | MEDLINE | ID: mdl-33564767
The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 1.5 million fatalities since it first emerged in late 2019. As we write, infection rates are currently at their highest point globally and are rising extremely rapidly in some areas due to more infectious variants. The primary viral target is the cellular receptor angiotensin-converting enzyme-2 (ACE2). Recent sequence analyses of the ACE2 gene predicts that many nonhuman primates are also likely to be highly susceptible to infection. However, the anticipated risk is not equal across the Order. Furthermore, some taxonomic groups show high ACE2 amino acid conservation, while others exhibit high variability at this locus. As an example of the latter, analyses of strepsirrhine primate ACE2 sequences to date indicate large variation among lemurs and lorises compared to other primate clades despite low sampling effort. Here, we report ACE2 gene and protein sequences for 71 individual strepsirrhines, spanning 51 species and 19 genera. Our study reinforces previous results and finds additional variability in other strepsirrhine species, and suggests several clades of lemurs have high potential susceptibility to SARS-CoV-2 infection. Troublingly, some species, including the rare and Endangered aye-aye (Daubentonia madagascariensis), as well as those in the genera Avahi and Propithecus, may be at high risk. Given that lemurs are endemic to Madagascar and among the primates at highest risk of extinction globally, further understanding of the potential threat of COVID-19 to their health should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Año: 2021 Tipo del documento: Article