Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives.
Front Endocrinol (Lausanne)
; 11: 613868, 2020.
Article
en En
| MEDLINE
| ID: mdl-33569042
ABSTRACT
Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons by activating transient receptor potential ion channels, specifically TRPA1 and TRPV1. Under inflammatory conditions, OxPL-mediated receptor potentials even potentiate the action potential firing rate of nociceptors. Targeting OxPL with D-4F, an apolipoprotein A-I mimetic peptide or antibodies like E06, specifically binding oxidized headgroups of phospholipids, can be used to control acute, inflammatory pain syndromes, at least in rodents. With a focus on proalgesic specificities of OxPL, this article discusses, how targeting defined substances of the epilipidome can contribute to mechanism-based therapies against primary and secondary chronic inflammatory or possibly also neuropathic pain.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dolor
/
Fosfolípidos
/
Sistemas de Liberación de Medicamentos
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Estrés Oxidativo
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Manejo del Dolor
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Analgésicos
Límite:
Animals
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Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article