5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro.
Biochem Biophys Res Commun
; 545: 203-207, 2021 03 19.
Article
en En
| MEDLINE
| ID: mdl-33571909
ABSTRACT
The current COVID-19 pandemic requires urgent development of effective therapeutics. 5-amino levulinic acid (5-ALA) is a naturally synthesized amino acid and has been used for multiple purposes including as an anticancer therapy and as a dietary supplement due to its high bioavailability. In this study, we demonstrated that 5-ALA treatment potently inhibited infection of SARS-CoV-2, a causative agent of COVID-19, in cell culture. The antiviral effects could be detected in both human and non-human cells, without significant cytotoxicity. Therefore, 5-ALA is worth to be further investigated as an antiviral drug candidate for COVID-19.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
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Tratamiento Farmacológico de COVID-19
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Ácidos Levulínicos
Límite:
Animals
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article