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Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity.
Zippilli, Claudio; Botta, Lorenzo; Bizzarri, Bruno Mattia; Nencioni, Lucia; De Angelis, Marta; Protto, Virginia; Giorgi, Gianluca; Baratto, Maria Camilla; Pogni, Rebecca; Saladino, Raffaele.
  • Zippilli C; Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, Italy.
  • Botta L; Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, Italy.
  • Bizzarri BM; Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, Italy.
  • Nencioni L; Department of Public Health and Infectious Diseases, Laboratory affiliated to Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
  • De Angelis M; Department of Public Health and Infectious Diseases, Laboratory affiliated to Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
  • Protto V; Department of Public Health and Infectious Diseases, Laboratory affiliated to Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.
  • Giorgi G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
  • Baratto MC; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
  • Pogni R; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
  • Saladino R; Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, Italy.
Int J Mol Sci ; 22(3)2021 Jan 29.
Article en En | MEDLINE | ID: mdl-33572794
ABSTRACT
Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Virus de la Influenza A / Óxidos / Polyporaceae / Lacasa / Dioxanos Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Virus de la Influenza A / Óxidos / Polyporaceae / Lacasa / Dioxanos Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article