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Massively parallel assessment of human variants with base editor screens.
Hanna, Ruth E; Hegde, Mudra; Fagre, Christian R; DeWeirdt, Peter C; Sangree, Annabel K; Szegletes, Zsofia; Griffith, Audrey; Feeley, Marissa N; Sanson, Kendall R; Baidi, Yossef; Koblan, Luke W; Liu, David R; Neal, James T; Doench, John G.
  • Hanna RE; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Hegde M; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Fagre CR; Cancer Program, Broad Institute, Cambridge, MA 02142, USA.
  • DeWeirdt PC; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Sangree AK; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Szegletes Z; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Griffith A; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Feeley MN; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Sanson KR; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Baidi Y; Cancer Program, Broad Institute, Cambridge, MA 02142, USA.
  • Koblan LW; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
  • Neal JT; Cancer Program, Broad Institute, Cambridge, MA 02142, USA.
  • Doench JG; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA. Electronic address: jdoench@broadinstitute.org.
Cell ; 184(4): 1064-1080.e20, 2021 02 18.
Article en En | MEDLINE | ID: mdl-33606977

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Variación Genética / Secuenciación de Nucleótidos de Alto Rendimiento / Edición Génica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Variación Genética / Secuenciación de Nucleótidos de Alto Rendimiento / Edición Génica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article