Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study.
J Diabetes Complications
; 35(5): 107873, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33627253
ABSTRACT
AIMS:
In individuals at increased risk of infections, e.g., patients with type 2 diabetes, low MBL may have detrimental effects. We used the Mendelian randomization principle to examine whether genetically low MBL is a risk factor for developing infections in patients with type 2 diabetes.METHODS:
Serum MBL (nâ¯=â¯7305) and MBL genotype (nâ¯=â¯3043) were determined in a nationwide cohort of patients with new type 2 diabetes and up to 8â¯years follow-up for hospital-treated infections and community-based antimicrobial prescriptions. The associations were examined in spline and Cox regression analyses.RESULTS:
1140 patients (16%) were hospitalized with an infection and 5077 patients (70%) redeemed an antimicrobial prescription. For low (≤100⯵g/L) versus intermediate (101-1000⯵g/L) serum MBL concentration, the adjusted hazard ratios (aHRs) were 1.13(95% confidence interval, 0.96-1.33) for any hospital-treated infections and 1.19(1.01-1.41) for bacterial infections. Low MBL expression genotype was not associated with risk of any hospital-treated infections except for diarrheal diseases (aHR 2.23[1.04-4.80]). Low MBL expression genotype, but not low serum MBL, was associated with increased risk for antimicrobial prescriptions (aHR 1.18[1.04-2.34] and antibacterial prescriptions 1.20[1.05-1.36]).CONCLUSIONS:
Low MBL is a weak causal risk factor for developing infections in patients with type 2 diabetes.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Lectina de Unión a Manosa
/
Diabetes Mellitus Tipo 2
/
Infecciones
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
País como asunto:
Europa
Idioma:
En
Año:
2021
Tipo del documento:
Article