Copper-Mediated Conversion of Alkynes into Nitriles via Iodotriazoles.

Kori, Ryosuke; Murakami, Keigo; Nishiyama, Yoshitake; Toma, Tatsuya; Yokoshima, Satoshi

Kori, Ryosuke; Murakami, Keigo; Nishiyama, Yoshitake; Toma, Tatsuya; Yokoshima, Satoshi.

Kori R; Graduate School of Pharmaceutical Sciences, Nagoya University.
Murakami K; Graduate School of Pharmaceutical Sciences, Nagoya University.
Nishiyama Y; Graduate School of Pharmaceutical Sciences, Nagoya University.
Toma T; Graduate School of Pharmaceutical Sciences, Nagoya University.
Yokoshima S; Graduate School of Pharmaceutical Sciences, Nagoya University.

Chem Pharm Bull (Tokyo) ; 69(3): 278-280, 2021.

Article en En | MEDLINE | ID: mdl-33642476

ABSTRACT

ABSTRACT

We disclose our studies on a copper-mediated reaction of alkynes with trimethylsilyl azide to afford nitriles, and proposed a reaction mechanism, which involves an iodoalkyne and an iodotriazole as intermediates.

Asunto(s)

Alquinos/química; Cobre/química; Nitrilos/química; Triazoles/química; Azidas/química; Azidas/metabolismo; Catálisis; Reacción de Cicloadición; Silanos/metabolismo; Solventes/química

Palabras clave

alkyne; azide; copper; cycloaddition; nitrile

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triazoles / Cobre / Alquinos / Nitrilos Idioma: En Año: 2021 Tipo del documento: Article

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PubMed Links

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triazoles / Cobre / Alquinos / Nitrilos Idioma: En Año: 2021 Tipo del documento: Article