Novel Inhibitors of Nicotinamide-<i>N</i>-Methyltransferase for the Treatment of Metabolic Disorders.

Kannt, Aimo; Rajagopal, Sridharan; Hallur, Mahanandeesha S; Swamy, Indu; Kristam, Rajendra; Dhakshinamoorthy, Saravanakumar; Czech, Joerg; Zech, Gernot; Schreuder, Herman; Ruf, Sven

Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders.

Kannt, Aimo; Rajagopal, Sridharan; Hallur, Mahanandeesha S; Swamy, Indu; Kristam, Rajendra; Dhakshinamoorthy, Saravanakumar; Czech, Joerg; Zech, Gernot; Schreuder, Herman; Ruf, Sven.

Kannt A; Fraunhofer Institute for Translational Medicine and Pharmacology-ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Rajagopal S; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India.
Hallur MS; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India.
Swamy I; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India.
Kristam R; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India.
Dhakshinamoorthy S; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India.
Czech J; Sanofi-Aventis Deutschland Gmbh, Industriepark Hoechst, 65926 Frankfurt am Main, Germany.
Zech G; Sanofi-Aventis Deutschland Gmbh, Industriepark Hoechst, 65926 Frankfurt am Main, Germany.
Schreuder H; Sanofi-Aventis Deutschland Gmbh, Industriepark Hoechst, 65926 Frankfurt am Main, Germany.
Ruf S; Sanofi-Aventis Deutschland Gmbh, Industriepark Hoechst, 65926 Frankfurt am Main, Germany.

Molecules ; 26(4)2021 Feb 13.

Article en En | MEDLINE | ID: mdl-33668468

Asunto(s)

Inhibidores Enzimáticos/uso terapéutico; Enfermedades Metabólicas/tratamiento farmacológico; Enfermedades Metabólicas/enzimología; Nicotinamida N-Metiltransferasa/antagonistas & inhibidores; Animales; Sitios de Unión; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/farmacología; Ensayos Analíticos de Alto Rendimiento; Humanos; Ligandos; Ratones; Microsomas Hepáticos/efectos de los fármacos; Microsomas Hepáticos/enzimología; Modelos Moleculares; Niacinamida/metabolismo; Nicotinamida N-Metiltransferasa/metabolismo; Ratas; Especificidad por Sustrato/efectos de los fármacos

Palabras clave

X-ray; metabolic disease; nicotinamide; nicotinamide-N-methyltransferase; small molecule inhibitor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Nicotinamida N-Metiltransferasa / Enfermedades Metabólicas Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

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