Lymph node stromal cell subsets-Emerging specialists for tailored tissue-specific immune responses.
Int J Med Microbiol
; 311(3): 151492, 2021 Apr.
Article
en En
| MEDLINE
| ID: mdl-33676241
ABSTRACT
The effective priming of adaptive immune responses depends on the precise dispatching of lymphocytes and antigens into and within lymph nodes (LNs), which are strategically dispersed throughout the body. Over the past decade, a growing body of evidence has advanced our understanding of lymph node stromal cells (LNSCs) from viewing them as mere accessory cells to seeing them as critical cellular players for the modulation of adaptive immune responses. In this review, we summarize current advances on the pivotal roles that LNSCs play in orchestrating adaptive immune responses during homeostasis and infection, and highlight the imprinting of location-specific information by micro-environmental cues into LNSCs, thereby tailoring tissue-specific immune responses.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Especialización
/
Células del Estroma
Idioma:
En
Año:
2021
Tipo del documento:
Article