M2 macrophage-derived exosomal microRNAs inhibit cell migration and invasion in gliomas through PI3K/AKT/mTOR signaling pathway.

Yao, Jie; Wang, Zefen; Cheng, Yong; Ma, Chao; Zhong, Yahua; Xiao, Yilei; Gao, Xu; Li, Zhiqiang

Yao, Jie; Wang, Zefen; Cheng, Yong; Ma, Chao; Zhong, Yahua; Xiao, Yilei; Gao, Xu; Li, Zhiqiang.

Yao J; Human Genetic Resources Conservation Center of Hubei Province, Wuhan, 430071, China.
Wang Z; Tumor Precision Diagnosis and Treatment Technology and Translation Medicine, Hubei Engineering Research Center, Wuhan, 430071, China.
Cheng Y; Department of Physiology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Ma C; Department of Neurology, Hankou Hospital, General Hospital of Central Theater Command of Chinese People's Liberation Army, Wuhan, 430014, China.
Zhong Y; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuhan, 430071, Hubei, China.
Xiao Y; Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Gao X; Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, 252000, China.
Li Z; Department of Neurosurgery, General Hospital of Northern Theater Command of People's Liberation Army, Shenyang, 110000, China.

J Transl Med ; 19(1): 99, 2021 03 06.

Article en En | MEDLINE | ID: mdl-33676540

Asunto(s)

Neoplasias Encefálicas/metabolismo; Exosomas/metabolismo; Glioma/metabolismo; Macrófagos/metabolismo; MicroARNs/metabolismo; Transducción de Señal; Neoplasias Encefálicas/patología; Línea Celular Tumoral; Movimiento Celular; Biología Computacional; Ciclina D1/metabolismo; Glioma/patología; Humanos; Microscopía Electrónica de Transmisión; Nanopartículas/química; Invasividad Neoplásica; Fosforilación; Proteínas Proto-Oncogénicas c-akt/metabolismo; Reacción en Cadena en Tiempo Real de la Polimerasa; Células THP-1; Serina-Treonina Quinasas TOR/metabolismo; Proteínas de Unión al GTP rap/metabolismo

Palabras clave

Exosome; Glioma; M2 macrophage; PI3K/AKT/mTOR; hsa-miR-15a-5p; hsa-miR-92a-3p

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Transducción de Señal / MicroARNs / Exosomas / Glioma / Macrófagos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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